Custom Proteins

OriGene offers comprehensive custom protein services starting from gene cloning through protein purification. Our services include custom modifications, and we provide the protein in your preferred buffer on request. Each protein undergoes established quality control checks before shipment.

Why Choose OriGene?s Custom Protein Service

For over twenty years, our mission has been to assist scientific communities by offering customized proteins. We are dedicated to continuing this support in the future.

• 20+ years experience in protein production
• Scalable for bulk production
• Custom modifications, mutations, conjugations, and formulations
• Affordable and risk-free process
• Dedicated Project Manager for your project
• Complete service 'Clone to protein'

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Service Highlights

• Three different Cell Based Expression Systems
• Complete service from cDNA cloning to protein purification, starting from any step
• Multiple tags with tag-free option also available
• Site specific enzymatic biotinylation (in vitro and in vivo)
• Post-translational modifications with native folding

"We are very happy with the HSD17B13 protein from OriGene and found great quality for our internal quality control. We?ve been very happy with your customer service as well and appreciated when there was a labeling mishap on one of the proteins OriGene promptly provided a new corrected protein sample."

~Scientist from a pharmaceutical company

Customer testimonial

Case Studies of Recombinant Protein Production Service

Available custom recombinant protein expression systems

Expression System	Common Applications	Advantages	Challenges
Mammalian	Functional and structural analysis Antibody production Protein interactions Production of enzyme in large scale Virus production	Most authentic human protein products Best preservation of native structure, function, and post-translational modifications Create stable production cell lines for scalable solutions	Complex culture conditions Costly set-up and maintenance Low yields Scaling difficulties
Insect	Functional and structural analysis Expression of protein complexes Expression of intracellular proteins Virus-like particles production	Post-translation modifications profile is similar to mammalian cells Effective protein folding More scalable than mammalian cells	Virus production can be time consuming Tricky to culture Infection can induce premature lysis
Bacterial	Structural analysis Antibody production Protein interactions Enzyme production Vaccine development	Simple vector construction Straightforward culture methods High yields Amenable to scaling	No post-translation modifications Improperly folded product Susceptible to aggregation Potential endotoxin contamination